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A mother who is O Rh negative gives birth to a baby who is A Rh positive

A mother who is O Rh negative gives birth to a baby who is A Rh positive

A mother who is O Rh negative gives birth to a baby who is A Rh positive. The baby has been diagnosed as having ABO HDFN and may need a transfusion. Please answer the following questions regarding this case.

Explain the mechanism by which fetal sensitization occurs in hemolytic disease of the fetus and newborn.

Which antibody is likely responsible for this ABO HDFN?

Why is bilirubinemia not a concern when the baby is in utero?

Why is it a concern after birth?

What blood type and what characteristics should the RBCs prepared for transfusion have?

A Kleihauer-Betke stain was performed on the mother’s blood and showed 2.5% fetal cells. How many vials of Rh immune globulin should be given to this woman?

List two ways in which you can safeguard against CMV infection from transfused blood products.

Why is ABO less severe than Rh HDFN?

Expert Answer


When the mother is Rh negative and the baby is Rh positive, then the fetus red blood cell acts as antibodies against the mother cells. This is called Rh-sensitization. These antibodies destroy the fetus red blood cells results in hemolytic disease of…
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